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Comparative Toxicogenomics Database

This chemical–disease association may be inferred in part via curated interactions between Eicosapentaenoic Acid and any genes listed below, and a curated association between those genes and Berylliosis.

		Reference	Association
1.		Sawyer RT, et al. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007 Feb;36(2):191-200.	Inferred via 1 gene: TNF
2.		Bekris LM, et al. Chronic beryllium disease and glutathione biosynthesis genes. J Occup Environ Med. 2006 Jun;48(6):599-606.	Inferred via 1 gene: GCLM
3.		Dotti C, et al. Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity. Sarcoidosis Vasc Diffuse Lung Dis. 2004 Mar;21(1):29-34.	Inferred via 1 gene: TNF
4.		Amicosante M, et al. HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells. Eur Respir J. 2002 Nov;20(5):1174-8.	Inferred via 1 gene: TNF
5.		Tinkle SS, et al. Beryllium induces IL-2 and IFN-gamma in berylliosis. J Immunol. 1997 Jan 1;158(1):518-26.	Inferred via 1 gene: IL2RA
6.		Bost T, et al. Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease. Chest. 1993 Feb;103(2 Suppl):138S.	Inferred via 2 genes: IL6 | TNF