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Comparative Toxicogenomics Database

This chemical–disease association may be inferred in part via curated interactions between 6-Aminonicotinamide and any genes listed below, and a curated association between those genes and Berylliosis.

		Reference	Association
1.		Jonth AC, et al. TGF-beta 1 variants in chronic beryllium disease and sarcoidosis. J Immunol. 2007 Sep 15;179(6):4255-62.	Inferred via 1 gene: TGFB1
2.		Sawyer RT, et al. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007 Feb;36(2):191-200.	Inferred via 1 gene: TNF
3.		Gaede KI, et al. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. J Mol Med (Berl). 2005 May;83(5):397-405.	Inferred via 1 gene: TGFB1
4.		Dotti C, et al. Analysis of TNF-alpha promoter polymorphisms in the susceptibility to beryllium hypersensitivity. Sarcoidosis Vasc Diffuse Lung Dis. 2004 Mar;21(1):29-34.	Inferred via 1 gene: TNF
5.		Amicosante M, et al. HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells. Eur Respir J. 2002 Nov;20(5):1174-8.	Inferred via 1 gene: TNF
6.		Bost T, et al. Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease. Chest. 1993 Feb;103(2 Suppl):138S.	Inferred via 2 genes: IL6 | TNF