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Chemical Aluminum

These diseases are associated with Aluminum or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 1,382 results.
  Chemical Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. Aluminum Alzheimer Disease M
22 genes: ABCA7 | ACE | ACHE | APP | BAX | CASP3 | ESR1 | F2 | HMOX1 | IDE | IGF1 | IL1B | MAPT | MPO | NPY | PICALM | PYY | SLC30A4 | SOD2 | TF | TNF | TREM2
15.75 60
Has associated exposure references.
2. Aluminum Lung Diseases M
15 genes: ACE | CLEC4E | HIF1A | IL13 | IRX1 | IRX2 | IRX3 | KIT | MPO | PTGS2 | PTH1R | PTHLH | SCGB1A1 | SOD2 | TNF
8.23 12
3. Aluminum Nerve Degeneration M
25 genes: AGTPBP1 | APP | ATXN3 | BAX | CASP3 | CDH1 | CNTF | EPOR | F2 | GST-1 | IGF1 | KCNJ6 | MAPK3 | NGFR | NOS1 | OTX2 | SEPP1 | SKN-1 | SLC1A2 | SLC6A3 | SMF-3 | SNCA | SOD2 | TNF | XDH
7.32 42
4. Aluminum Poisoning M
3 genes: ACHE | ALB | SLC22A2
6.60 8
5. Aluminum Amyotrophic Lateral Sclerosis M
7 genes: GFAP | GSR | PLA2G4A | PTGS2 | SLC1A2 | SOD2 | UNC13A
6.38 7
6. Aluminum Neurodegenerative Diseases M
10 genes: APOD | APP | CRYAB | GSR | HMOX1 | MAPT | NGFR | SEPP1 | SNCA | SOD2
5.31 13
7. Aluminum Dyslipidemias M   1 gene: APOB 3.77 2
8. Aluminum Osteoporosis M
8 genes: CA2 | CALCR | GPX1 | IDH2 | LTF | PTH | SOD2 | VDR
3.41 10
9. Aluminum Cognition Disorders M
5 genes: APP | DRD2 | MAPT | PTGS2 | SLC4A10
3.29 9
10. Aluminum Fragile X Syndrome M   1 gene: APP 3.17 2
11. Aluminum Brain Diseases M
4 genes: ALB | APP | IFNB1 | MPO
3.01 7
12. Aluminum Bronchial Hyperreactivity M
2 genes: IL13 | TRPA1
3.00 4
13. Aluminum Memory Disorders M
7 genes: ACHE | APP | DRD2 | IL1B | MAPT | NPY | SLC6A3
2.89 18
14. Aluminum Parkinson Disease M
11 genes: DRD1 | DRD2 | GFAP | GPX1 | HMOX1 | MAPT | NOS1 | SLC6A3 | SNCA | SOD2 | TNF
2.84 36
Has associated exposure references.
15. Aluminum Autism Spectrum Disorder M
4 genes: MEF2C | NRXN1 | SCN1A | SLC16A2
2.68 5
16. Aluminum Diabetes Complications M   1 gene: HIF1A 2.66 2
17. Aluminum Nervous System Diseases M
14 genes: ACHE | CASP3 | EN1 | FOS | GFAP | ID3 | NFATC2 | NOS1 | PTGS2 | SEPP1 | SLC19A1 | SLC2A1 | SLC6A3 | TNF
2.57 17
18. Aluminum Inflammation M
23 genes: ADIPOQ | BDKRB2 | CD3E | COL2A1 | CXCL8 | EFNB1 | HMOX1 | IL13 | IL1B | LTF | MMP2 | MMP9 | MPO | NOS2 | PTGS2 | SCGB1A1 | SLC22A5 | TF | TFRC | TLR2 | TNF | TRPA1 | ZFP36
2.55 45
19. Aluminum Neurotoxicity Syndromes M
5 genes: ALOX5AP | CASP3 | CD3D | FOS | RNASE6
2.45 4
20. Aluminum Neoplasms M
14 genes: APOBEC3A | ATF2 | CAT | GLP1R | HSF1 | IL18 | IL1B | IL2 | KDM6A | LTF | NAT1 | PTGS2 | SOD2 | VDR
2.23 20
21. Aluminum Anemia M
8 genes: ATG7 | GSR | IFNA2 | IL2 | IL3 | PTH | SOD2 | TNF
2.16 15
22. Aluminum Epilepsy, Tonic-Clonic M     1
23. Aluminum Eye Diseases M     1
24. Aluminum Granuloma M     1
25. Aluminum Heavy Metal Toxicity M     1
26. Aluminum Lymphadenitis M     1
27. Aluminum Multiple Sclerosis, Chronic Progressive M     1
28. Aluminum Multiple Sclerosis, Relapsing-Remitting M     1
29. Aluminum Osteomalacia M     1
30. Aluminum Renal Osteodystrophy M     1
31. Aluminum Liver Cirrhosis, Experimental  
91 genes: ABCG8 | ACHE | ADIPOQ | ADM | AFM | AFP | ALB | ALDH1A1 | ALDH1L2 | APP | ARHGDIB | BBOX1 | C5AR1 | CCNB2 | CD163 | CD36 | CD38 | CD5L | CD74 | COL5A2 | CRTAP | CRYAB | CTSS | CXCL12 | CXCL13 | EIF4E3 | FCER1G | FOLR2 | FOS | FTCD | GCHFR | GMFG | GNAI2 | HEXIM1 | HIP1 | HMOX1 | IFNA1 | IFNA2 | IGF1 | IGSF6 | IL18 | IL1B | IL33 | ISYNA1 | ITGA2B | KLF6 | L3HYPDH | LAPTM5 | LCP1 | LCP2 | LGALSL | LMO2 | LRAT | LY86 | MGAT5 | MME | MMP1 | MMP2 | MMP9 | MRO | NCKAP1L | NEK6 | NOS2 | OSM | OTUB2 | PKLR | PLA2G4A | PQLC3 | PRKCB | PRUNE2 | PTGS2 | PTPRC | PTRH1 | PYCARD | RCSD1 | RDH10 | RNF39 | ROBO2 | RTP3 | S1PR1 | SEPP1 | SERPINA7 | SLA | SLC17A2 | SLC22A8 | SPIN2A | SPSB4 | TFEC | TMEM43 | TNF | TRF
46.25 26
32. Aluminum Autistic Disorder  
38 genes: ADM | AR | CACNA1H | CAT | DRD1 | GPX1 | HDLBP | HOXD11 | HTR1B | HTR1D | HTR5A | IGF1 | IL13 | IL15 | IL2 | IL4 | IL5 | LASP1 | MAGEL2 | MEF2C | NF1 | NOS2 | NRXN1 | PDE4B | PECAM1 | PIK3CG | PLA2G4A | PRKCB | PTGS2 | ROBO2 | SHANK2 | SLC19A1 | SLC1A3 | SLC6A8 | TDO2 | TF | TNFRSF1B | XDH
25.53 40
33. Aluminum Obesity  
32 genes: ACLY | ADH1B | ADIPOQ | ADRB1 | AKAP1 | CES1 | CPB2 | CTF1 | CTSS | EFNB1 | EP300 | ESR1 | F2 | GNPDA2 | GPX1 | HMOX1 | HOXB5 | MMP9 | NAMPT | NHLH2 | NPY5R | PACS1 | PCSK1 | PTGS2 | PYY | SIM1 | SOD2 | TF | TFRC | TNF | TNFRSF1B | UCP1
22.83 33
34. Aluminum Breast Neoplasms  
64 genes: ACHE | AFP | APOBEC3A | AR | ARHGDIA | BAX | BCL2A1 | C10ORF10 | CAT | CD74 | CDH1 | CLUL1 | COL7A1 | CUL5 | CXCL12 | CXCL8 | EP300 | EPOR | ERBB3 | ESR1 | FOS | FOXP3 | GNAI2 | GPX1 | HEYL | HIF1A | HMOX1 | HNRNPR | HOXD11 | IFNB1 | IGF1 | IL1B | JUN | KIT | KRT5 | MAL | MECOM | MED12 | MME | MMP1 | MMP2 | MMP9 | MTR | NMBR | NOS2 | PGR | PLA2G4A | PTGS2 | PTHLH | RAD51B | RELA | RIBC2 | RNF115 | SFRP5 | SIM1 | SLC2A1 | SNAI1 | SOD2 | TFRC | TNF | TNFSF10 | VDR | WHSC1 | WWOX
22.08 76
35. Aluminum Arthritis, Rheumatoid  
30 genes: ADIPOQ | BAIAP2L1 | BCL2A1 | BDKRB2 | BLK | CAT | CD3E | CD5 | CXCL6 | CXCL8 | F2 | FASLG | FOXP3 | GPRC5A | HOXD11 | HOXD13 | IL18 | IL1B | MMP2 | MPO | POU3F1 | PRDM1 | PTGS2 | PTPN22 | PTPRC | RGMB | SOD2 | TAGAP | TLR2 | TNF
20.35 22
36. Aluminum Prostatic Neoplasms  
54 genes: ABR | ACE | ACHE | ACSL4 | ALAD | AR | BAX | BCAS1 | BGLAP | BRAF | CDH1 | CRYAB | CXCL12 | CXCL8 | CYP7B1 | ERBB3 | ESR1 | FASLG | FOXP4 | HIF1A | HIP1 | HSD3B1 | HSD3B2 | ID3 | IGF1 | IL18 | IL2 | KLF6 | LAMB2 | MAPK3 | MBD2 | MED12 | MME | MMP9 | MPO | MSR1 | MUC4 | MYH14 | NAT1 | NGFR | OLFM1 | PRRX1 | PTGS2 | PTHLH | SEPP1 | SESN3 | SOD2 | TIRAP | TMF1 | TNFSF10 | TPD52L1 | USO1 | VDR | ZBTB16
18.95 72
Has associated exposure references.
37. Aluminum Endometriosis  
23 genes: C10ORF10 | CD226 | CNIH3 | FOS | IGF1 | IL15 | IL1R1 | ITGA2 | LTF | MED16 | NEFM | NR3C2 | NR4A1 | OSR2 | PAPPA | PGR | PLXNC1 | PTGS2 | RASL11A | RORB | RXFP1 | SEPP1 | THRA
18.07 6
38. Aluminum Colorectal Neoplasms  
31 genes: ABCA1 | ABCA10 | ABCA8 | ADH1B | BRAF | CD226 | CDH1 | COL7A1 | CXCL8 | EP300 | FLCN | GRID1 | IFNA1 | IFNA2 | MMP1 | MMP2 | NAMPT | PRKCB | PRKCE | PTGS2 | PYCARD | SEPP1 | SFRP5 | SLC19A1 | SOD2 | TFRC | TGFBR1 | TLR2 | TNF | TNFSF10 | ZNF292
16.75 35
39. Aluminum Amphetamine-Related Disorders  
18 genes: ACHE | DRD1 | DRD2 | FOS | GABRG2 | HTR1B | MAP2K5 | MARC1 | NOS1 | OPRM1 | PDE4B | POU5F1 | PRKG1 | PSD3 | RAPGEF5 | RELA | SLC6A3 | SNCA
14.90 13
40. Aluminum Radiation Injuries, Experimental  
7 genes: HIF1A | IL18 | IL1B | MAPK3 | NOS1 | SOD2 | TNF
14.37 4
41. Aluminum Brain Injuries  
21 genes: ALB | CES1 | CHRM2 | CLEC4E | FOS | IL12RB2 | IL13RA2 | IL1B | IL1R1 | IL2 | JUN | LY86 | MMP9 | MPO | PGLYRP1 | PTGS2 | S100B | SOD2 | TLR2 | TNF | TNFSF10
13.04 12
42. Aluminum Reperfusion Injury  
21 genes: CASP3 | CAT | CD36 | CHAT | CXCL8 | EFNA5 | FOS | GPX1 | HMOX1 | ID3 | IL1B | JUN | MMP9 | MPO | NOS2 | PTGS2 | RELA | SOD2 | TLR2 | TNF | XDH
12.97 35
43. Aluminum Neoplasm Invasiveness  
26 genes: ACO1 | AMBP | CAT | CDH1 | CTSS | CXCL12 | EN1 | EPOR | FGF16 | GAB2 | HIF1A | HMOX1 | IGF1 | ITPK1 | MAPK3 | MMP1 | MMP2 | MMP9 | RELA | SNAI1 | SOD2 | TBX15 | TF | TNF | ZBTB16 | ZFP36
12.81 34
44. Aluminum Liver Cirrhosis, Alcoholic  
7 genes: CAT | MMP2 | MPO | RELA | SOD2 | TM6SF2 | TNF
12.49 3
45. Aluminum Brain Ischemia  
19 genes: ACE | ALB | CASP3 | CAT | F2 | GPX1 | HIF1A | IL18 | IL1B | JUN | MAPK3 | MMP9 | MPO | NOS2 | PTGS2 | RELA | SOD2 | TNF | TNFRSF1B
12.48 17
46. fluoroaluminum Adrenocortical Carcinoma  
2 genes: ABCB1 | IGF2
12.22 3
47. Aluminum Amyotrophic lateral sclerosis 1  
10 genes: CALB2 | CNTF | FOS | GFAP | GRIA3 | HSF1 | NEFH | SNAI1 | TNF | WNT7A
12.14 5
48. fluoroaluminum Carcinoma, Hepatocellular  
3 genes: ABCB1 | IGF2 | PTK2
11.88 4
49. Aluminum Diabetes Mellitus, Experimental  
21 genes: ACE | BAX | CASP3 | CAT | CHRM2 | GPX1 | GSR | HK1 | HMOX1 | IGF1 | IL1B | MMP2 | MMP9 | MPO | NOS2 | PKLR | PRKCE | PTGS2 | RELA | SOD2 | TNF
11.74 24
50. Aluminum Melanoma  
27 genes: BRAF | CNNM1 | COL2A1 | EDA | EP300 | EPB41 | EPOR | FASLG | GAB2 | GNAQ | GPHA2 | IFNA1 | IFNA2 | IFNB1 | IL2 | MX2 | NF1 | PDCD1 | PTGS2 | QPCT | SLC25A45 | SLC6A11 | TMEM132B | TNF | TRRAP | USP6NL | VGLL2
11.57 67
1–50 of 1,382 results.