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Chemical Aluminum

These diseases are associated with Aluminum or its descendants. Each association is curated (M marker/mechanism and/or T therapeutic) and/or inferred (via a curated gene interaction).

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1–50 of 1,344 results.
  Chemical Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. Aluminum Alzheimer Disease M
22 genes: ABCA7 | ACE | ACHE | APP | BAX | CASP3 | ESR1 | F2 | HMOX1 | IDE | IGF1 | IL1B | MAPT | MPO | NPY | PICALM | PYY | SLC30A4 | SOD2 | TF | TNF | TREM2
15.64 57
Has associated exposure references.
2. Aluminum Lung Diseases M
15 genes: ACE | CLEC4E | HIF1A | IL13 | IRX1 | IRX2 | IRX3 | KIT | MPO | PTGS2 | PTH1R | PTHLH | SCGB1A1 | SOD2 | TNF
7.97 12
3. Aluminum Nerve Degeneration M
25 genes: AGTPBP1 | APP | ATXN3 | BAX | CASP3 | CDH1 | CELE_R107.7 | CELE_T19E7.2 | CELE_Y69A2AR.4 | CNTF | EPOR | F2 | IGF1 | KCNJ6 | MAPK3 | NGFR | NOS1 | OTX2 | SEPP1 | SLC1A2 | SLC6A3 | SNCA | SOD2 | TNF | XDH
7.05 40
4. Aluminum Poisoning M
3 genes: ACHE | ALB | SLC22A2
6.78 8
5. Aluminum Amyotrophic Lateral Sclerosis M
7 genes: GFAP | GSR | PLA2G4A | PTGS2 | SLC1A2 | SOD2 | UNC13A
6.09 7
6. Aluminum Neurodegenerative Diseases M
10 genes: APOD | APP | CRYAB | GSR | HMOX1 | MAPT | NGFR | SEPP1 | SNCA | SOD2
5.46 13
7. Aluminum Cognition Disorders M
4 genes: APP | DRD2 | PTGS2 | SLC4A10
4.31 8
8. Aluminum Dyslipidemias M   1 gene: APOB 3.74 2
9. Aluminum Brain Diseases M
4 genes: ALB | APP | IFNB1 | MPO
3.21 7
10. Aluminum Memory Disorders M
6 genes: ACHE | APP | IL1B | MAPT | NPY | SLC6A3
3.16 13
11. Aluminum Fragile X Syndrome M   1 gene: APP 3.15 2
12. Aluminum Bronchial Hyperreactivity M
2 genes: IL13 | TRPA1
3.00 4
13. Aluminum Child Development Disorders, Pervasive M
4 genes: MEF2C | NRXN1 | SCN1A | SLC16A2
2.58 5
14. Aluminum Inflammation M
23 genes: ADIPOQ | BDKRB2 | CD3E | COL2A1 | CXCL8 | EFNB1 | HMOX1 | IL13 | IL1B | LTF | MMP2 | MMP9 | MPO | NOS2 | PTGS2 | SCGB1A1 | SLC22A5 | TF | TFRC | TLR2 | TNF | TRPA1 | ZFP36
2.55 45
15. Aluminum Anemia M
7 genes: GSR | IFNA2 | IL2 | IL3 | PTH | SOD2 | TNF
2.52 14
16. Aluminum Neurotoxicity Syndromes M
5 genes: ALOX5AP | CASP3 | CD3D | FOS | RNASE6
2.49 4
17. Aluminum Nervous System Diseases M
14 genes: ACHE | CASP3 | EN1 | FOS | GFAP | ID3 | NFATC2 | NOS1 | PTGS2 | SEPP1 | SLC19A1 | SLC2A1 | SLC6A3 | TNF
2.44 17
18. Aluminum Parkinson Disease M
10 genes: DRD1 | DRD2 | GFAP | GPX1 | HMOX1 | MAPT | SLC6A3 | SNCA | SOD2 | TNF
2.39 35
Has associated exposure references.
19. Aluminum Neoplasms M
13 genes: ATF2 | CAT | GLP1R | HSF1 | IL18 | IL1B | IL2 | KDM6A | LTF | NAT1 | PTGS2 | SOD2 | VDR
2.25 19
20. Aluminum Diabetes Complications M     1
21. Aluminum Epilepsy, Tonic-Clonic M     1
22. Aluminum Eye Diseases M     1
23. Aluminum Granuloma M     1
24. Aluminum Heavy Metal Toxicity M     1
25. Aluminum Lymphadenitis M     1
26. Aluminum Multiple Sclerosis, Chronic Progressive M     1
27. Aluminum Multiple Sclerosis, Relapsing-Remitting M     1
28. Aluminum Osteomalacia M     1
29. Aluminum Renal Osteodystrophy M     1
30. Aluminum Autistic Disorder  
38 genes: ADM | AR | CACNA1H | CAT | DRD1 | GPX1 | HDLBP | HOXD11 | HTR1B | HTR1D | HTR5A | IGF1 | IL13 | IL15 | IL2 | IL4 | IL5 | LASP1 | MAGEL2 | MEF2C | NF1 | NOS2 | NRXN1 | PDE4B | PECAM1 | PIK3CG | PLA2G4A | PRKCB | PTGS2 | ROBO2 | SHANK2 | SLC19A1 | SLC1A3 | SLC6A8 | TDO2 | TF | TNFRSF1B | XDH
24.38 40
31. Aluminum Glomerulonephritis, IGA  
45 genes: ABCA1 | ACE | AKIRIN1 | ALOX5AP | C5AR1 | CCNB2 | CD163 | CD36 | CTSS | FAM3A | HJURP | HMOX1 | IL10RA | ITCH | ITGA2 | KIF18A | LAIR1 | LAPTM5 | LAT2 | LCP1 | LHFPL2 | LITAF | MMP1 | MMP9 | MSR1 | NAMPT | NCKAP1L | NDC1 | NEK4 | PTHLH | PTPN22 | PTPRC | PTX3 | RASA1 | RCOR1 | RFWD3 | RNASE2 | RNASE6 | SLC1A3 | SLC43A3 | STX6 | TFEC | TLR2 | TTK | YES1
23.96 3
32. Aluminum Obesity  
31 genes: ACLY | ADH1B | ADIPOQ | ADRB1 | AKAP1 | CES1 | CPB2 | CTF1 | CTSS | EFNB1 | ESR1 | F2 | GNPDA2 | GPX1 | HMOX1 | HOXB5 | MMP9 | NAMPT | NHLH2 | NPY5R | PACS1 | PCSK1 | PTGS2 | PYY | SIM1 | SOD2 | TF | TFRC | TNF | TNFRSF1B | UCP1
20.46 32
33. Aluminum Endometriosis  
23 genes: C10ORF10 | CD226 | CNIH3 | FOS | IGF1 | IL15 | IL1R1 | ITGA2 | LTF | MED16 | NEFM | NR3C2 | NR4A1 | OSR2 | PAPPA | PGR | PLXNC1 | PTGS2 | RASL11A | RORB | RXFP1 | SEPP1 | THRA
17.08 6
34. Aluminum Down Syndrome  
17 genes: ADAMTS5 | APP | B3GALT5 | BRWD1 | CLDN14 | CLDN8 | CLIC6 | CXCL8 | GATA1 | GRIK1 | KCNJ15 | KCNJ6 | MTR | MX2 | OLIG2 | S100B | SLC19A1
16.80 6
35. Aluminum Breast Neoplasms  
58 genes: ACHE | AFP | APOBEC3A | AR | ARHGDIA | BAX | BCL2A1 | C10ORF10 | CAT | CD74 | CDH1 | CLUL1 | COL7A1 | CUL5 | CXCL12 | CXCL8 | EPOR | ESR1 | FOS | FOXP3 | GPX1 | HEYL | HIF1A | HMOX1 | HNRNPR | HOXD11 | IFNB1 | IGF1 | IL1B | JUN | KIT | MAL | MECOM | MED12 | MME | MMP1 | MMP2 | MMP9 | MTR | NMBR | NOS2 | PGR | PLA2G4A | PTGS2 | PTHLH | RAD51B | RELA | RIBC2 | RNF115 | SFRP5 | SIM1 | SLC2A1 | SNAI1 | SOD2 | TFRC | TNF | TNFSF10 | WWOX
16.71 68
36. Aluminum Colorectal Neoplasms  
31 genes: ABCA1 | ABCA10 | ABCA8 | ADH1B | BRAF | CD226 | CDH1 | COL7A1 | CXCL8 | EP300 | FLCN | GRID1 | IFNA1 | IFNA2 | MMP1 | MMP2 | NAMPT | PRKCB | PRKCE | PTGS2 | PYCARD | SEPP1 | SFRP5 | SLC19A1 | SOD2 | TFRC | TGFBR1 | TLR2 | TNF | TNFSF10 | ZNF292
15.88 34
37. Aluminum Peripheral Nervous System Diseases  
41 genes: ABCA1 | AICDA | ALDH1A1 | APOB | ARSA | BAX | CEP250 | CES1 | DBH | ESR1 | FMO3 | GFAP | GPR15 | GPX1 | GZMH | ID3 | IFNA1 | IGF1 | IL18 | IL2 | IL3 | JUN | MN1 | MTR | NAT1 | NEFH | NEK4 | NPY | PIK3CG | PLXDC2 | PRKCE | PTGIS | SIM1 | SLC22A5 | SLC22A8 | SOD2 | TLN2 | TNF | TNFSF8 | UCP1 | WNT11
15.09 7
38. Aluminum Amphetamine-Related Disorders  
18 genes: ACHE | DRD1 | DRD2 | FOS | GABRG2 | HTR1B | MAP2K5 | MARC1 | NOS1 | OPRM1 | PDE4B | POU5F1 | PRKG1 | PSD3 | RAPGEF5 | RELA | SLC6A3 | SNCA
14.22 13
39. Aluminum Arthritis, Rheumatoid  
23 genes: ADIPOQ | BAIAP2L1 | BDKRB2 | BLK | CAT | CD3E | CD5 | CXCL6 | HOXD11 | HOXD13 | IL18 | IL1B | MMP2 | MPO | POU3F1 | PRDM1 | PTGS2 | PTPN22 | PTPRC | RGMB | SOD2 | TAGAP | TNF
14.10 17
40. Aluminum Prostatic Neoplasms  
48 genes: ACE | ACHE | ACSL4 | AR | BAX | BCAS1 | BGLAP | CDH1 | CRYAB | CXCL12 | CXCL8 | CYP7B1 | ERBB3 | ESR1 | FASLG | FOXP4 | HIF1A | HIP1 | HSD3B1 | HSD3B2 | ID3 | IGF1 | IL18 | IL2 | KLF6 | LAMB2 | MBD2 | MED12 | MME | MMP9 | MPO | MSR1 | MUC4 | MYH14 | NAT1 | NGFR | OLFM1 | PRRX1 | PTGS2 | PTHLH | SEPP1 | SOD2 | TIRAP | TMF1 | TNFSF10 | TPD52L1 | USO1 | VDR
13.63 64
Has associated exposure references.
41. Aluminum Brain Injuries  
21 genes: ALB | CES1 | CHRM2 | CLEC4E | FOS | IL12RB2 | IL13RA2 | IL1B | IL1R1 | IL2 | JUN | LY86 | MMP9 | MPO | PGLYRP1 | PTGS2 | S100B | SOD2 | TLR2 | TNF | TNFSF10
12.95 12
42. Aluminum Amyotrophic lateral sclerosis 1  
10 genes: CALB2 | CNTF | FOS | GFAP | GRIA3 | HSF1 | NEFH | SNAI1 | TNF | WNT7A
12.17 5
43. fluoroaluminum Adrenocortical Carcinoma  
2 genes: ABCB1 | IGF2
12.14 3
44. Aluminum Radiation Injuries, Experimental  
6 genes: IL18 | IL1B | MAPK3 | NOS1 | SOD2 | TNF
11.94 3
45. Aluminum Reperfusion Injury  
20 genes: CASP3 | CAT | CD36 | CHAT | CXCL8 | EFNA5 | FOS | GPX1 | HMOX1 | ID3 | IL1B | JUN | MMP9 | MPO | NOS2 | PTGS2 | RELA | SOD2 | TNF | XDH
11.93 34
46. fluoroaluminum Carcinoma, Hepatocellular  
3 genes: ABCB1 | IGF2 | PTK2
11.77 4
47. Aluminum Brain Ischemia  
19 genes: ACE | ALB | CASP3 | CAT | F2 | GPX1 | HIF1A | IL18 | IL1B | JUN | MAPK3 | MMP9 | MPO | NOS2 | PTGS2 | RELA | SOD2 | TNF | TNFRSF1B
11.72 17
48. Aluminum Diabetes Mellitus, Experimental  
21 genes: ACE | BAX | CASP3 | CAT | CHRM2 | GPX1 | GSR | HK1 | HMOX1 | IGF1 | IL1B | MMP2 | MMP9 | MPO | NOS2 | PKLR | PRKCE | PTGS2 | RELA | SOD2 | TNF
11.33 24
49. Aluminum Nausea  
2 genes: IFNA2 | TNF
11.29 4
50. Aluminum Calcinosis  
10 genes: AHSG | BGLAP | C6 | CASP3 | IL18 | IL1B | LY86 | MMP2 | MMP9 | PYCARD
11.03 4
1–50 of 1,344 results.