Giving insight into how chemicals affect our health.
Comparative Toxicogenomics Database

Contents

1. Curated Chemical–Gene Interactions
2. Chemical–Disease Associations
3. Gene–Disease Associations
4. Chemical–Pathway Enriched Associations
5. Disease–Pathway Associations
6. Gene–Pathway Associations
7. Chemical–GO-Term Enriched Associations
8. Chemicals
9. Diseases (MEDIC)
10. Genes
11. Pathways
12. Chemical–Gene Interaction Types
13. Exposure Ontology

Top Curated Chemical–Gene Interactions

Fields:

1. ChemicalName
2. ChemicalID (MeSH accession identifier)
3. CasRN
4. GeneSymbol
5. GeneID (NCBI Gene accession identifier)
6. Organism (scientific name)
7. OrganismID (NCBI Taxonomy accession identifier)
8. Interaction
9. InteractionActions ('|'-delimited list)
10. PubmedIDs ('|'-delimited list)

Top Chemical–Disease Associations

Fields:

1. ChemicalName
2. ChemicalID (MeSH accession identifier)
3. CasRN
4. DiseaseName
5. DiseaseID (MeSH or OMIM accession identifier)
6. DirectEvidence ('|'-delimited list)
7. InferenceGeneSymbol
8. InferenceScore
9. OmimIDs ('|'-delimited list)
10. PubmedIDs ('|'-delimited list)

Top Gene–Disease Associations

Fields:

1. GeneSymbol
2. GeneID (NCBI Gene accession identifier)
3. DiseaseName
4. DiseaseID (MeSH or OMIM accession identifier)
5. DirectEvidence ('|'-delimited list)
6. InferenceChemicalName
7. InferenceScore
8. OmimIDs ('|'-delimited list)
9. PubmedIDs ('|'-delimited list)

Top Chemical–Pathway Enriched Associations

Fields:

1. ChemicalName
2. ChemicalID (MeSH accession identifier)
3. CasRN
4. PathwayName
5. PathwayID (KEGG or REACTOME accession identifier)
6. EnrichmentScore
7. TargetMatchQty
8. TargetTotalQty
9. BackgroundMatchQty
10. BackgroundTotalQty

Top Disease–Pathway Associations

Fields:

1. DiseaseName
2. DiseaseID (MeSH or OMIM accession identifier)
3. PathwayName
4. PathwayID (KEGG or REACTOME accession identifier)
5. InferenceGeneSymbol (a gene via which the association is inferred)

Top Gene–Pathway Associations

Fields:

1. GeneSymbol
2. GeneID (NCBI Gene accession identifier)
3. PathwayName
4. PathwayID (KEGG or REACTOME accession identifier)

Top Chemical–GO-Term Enriched Associations

To provide insight into the biological properties that may be affected by a particular chemical, CTD calculates GO terms that are statistically enriched among the genes/proteins that interact with a chemical or its descendants. More…

Fields:

1. ChemicalName
2. ChemicalID (MeSH accession identifier)
3. CasRN
4. Ontology
5. GOTermName
6. GOTermID
7. HighestGOLevel
8. EnrichmentScore
9. TargetMatchQty
10. TargetTotalQty
11. BackgroundMatchQty
12. BackgroundTotalQty

Top Chemicals

Each chemical occurs in at least one node of the hierarchy. Nodes are identified by their unique ChemicalTreeNumber. To navigate the hierarchy, use the ParentIDs or ParentTreeNumbers field. More…

Fields:

1. ChemicalName
2. ChemicalID (MeSH accession identifier)
3. CasRN
4. ParentIDs (accession identifiers of the parent terms; '|'-delimited list)
5. ChemicalTreeNumbers (unique identifiers of the chemical's nodes; '|'-delimited list)
6. ParentTreeNumbers (unique identifiers of the parent nodes; '|'-delimited list)
7. Synonyms ('|'-delimited list)

Use Chemical IDs to link to CTD chemical pages.

Top Diseases (MEDIC)

Each disease in the MEDIC vocabulary occurs in at least one node of the hierarchy. Nodes are identified by their unique DiseaseTreeNumber. To navigate the hierarchy, use the ParentIDs or ParentTreeNumbers field. More…

Fields (non-OBO):

1. DiseaseName
2. DiseaseID (primary MeSH or OMIM accession identifier)
3. AltDiseaseIDs (alternative accession identifiers; '|'-delimited list)
4. ParentIDs (primary accession identifiers of the parent terms; '|'-delimited list)
5. DiseaseTreeNumbers (unique identifiers of the disease's nodes; '|'-delimited list)
6. ParentTreeNumbers (unique identifiers of the parent nodes; '|'-delimited list)
7. Synonyms ('|'-delimited list)

Use DiseaseIDs to link to CTD disease pages.

Top Genes

Fields:

1. GeneSymbol
2. GeneName
3. GeneID (primary NCBI Gene accession identifier)
4. AltGeneIDs (alternative NCBI Gene accession identifiers; '|'-delimited list)
5. Synonyms ('|'-delimited list)

Use GeneIDs to link to CTD gene pages.

Top Pathways

Fields:

1. PathwayName
2. PathwayID (OMIM or REACTOME accession identifier)

Use PathwayIDs to link to CTD pathway pages.

Top Chemical–Gene Interaction Types

CTD curates chemical–gene and –protein interactions in vertebrates and invertebrates using this hierarchical vocabulary of interaction types. To navigate the tree hierarchy, use the ParentCode field. More…

Fields (non-OBO):

1. TypeName
2. Code
3. Description
4. ParentCode

Top Exposure Ontology

The draft Exposure Ontology (ExO) will provide exposure context for CTD data. More…