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Help: Disease Chemical–Gene Interactions


CTD curates specific chemical–gene and protein interactions in vertebrates and invertebrates from the published literature. Most interactions are binary, involving one chemical and one gene or protein (e.g., “3-methylquercetin results in decreased activity of ABCC1 protein”). Brackets represent nested events in more complex interactions (e.g., “[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA”).

These interactions are connected to diseases in CTD via interactions involving genes that are associated with the disease subject of this page. The following data is presented for this disease:

  1. The interacting chemical (a chemical that interacts with a gene associated with the disease subject of this page, or one of that chemical's children).
  2. The interacting gene associated with the disease subject of this page.
  3. The description of the interaction, with color-coded action degrees:
    • increases
    • decreases
    • affects (degree unspecified)
  4. The number of references reporting the interaction. Click to view the reporting references and organisms.
  5. The number of organisms in which the interaction was reported. Click to view the reporting references and organisms.

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Download

Save these data into a comma-separated values (CSV), Excel, XML, or tab-separated values (TSV) file by clicking a Download link at the bottom of the table.