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Giving insight into how chemicals affect our health.CTD curates specific chemical–gene and protein interactions in vertebrates and invertebrates from the published literature. Most interactions are binary, involving one chemical and one gene or protein (e.g., “3-methylquercetin results in decreased activity of ABCC1 protein”). Brackets represent nested events in more complex interactions (e.g., “[3,4,5,3',4'-pentachlorobiphenyl binds to AHR protein] which results in increased expression of ABCC3 mRNA”).
Interaction query results are presented in a tabular format that shows the interacting genes and chemicals, organism, and reporting reference for each interaction. A single interaction may be represented several times in this table: once for each unique combination of chemical, gene, and reference.
From the results page, you may access detail pages about the interacting genes and chemicals, organisms, and references.
The name of an interacting chemical in the interaction. Click the chemical name to view the chemical's detail page.
The symbol of an interacting gene in the interaction. Click the gene symbol to view the gene's detail page.
The description of the interaction.
Action degrees are color-coded by category:
The number of references reporting the interaction. Click to view the reporting references and organisms.
The number of organisms in which the interaction was reported and which match the current query. Click to view the reporting references and organisms.
Sort these data differently by clicking a column heading.
Save these data into a comma-separated values (CSV), Excel, XML, or tab-separated values (TSV) file by clicking a Download link at the bottom of the table.